hyalusupp suppositories

Hyaluronic acid and sodium hyaluronate are biologically significant compounds that play a key role in maintaining moisture, tissue repair, and facilitating regeneration. Due to their high capacity for water absorption and retention, these substances are essential structural components of skin and cartilage, contributing to extracellular space hydration, inflammation reduction, softness, and increased skin elasticity. Additionally, by storing growth factors in the extracellular matrix, they facilitate the binding of these factors to cell surface receptors and initiate tissue repair processes upon injury. Estrogen decline, especially during menopause, causes unfavorable changes in organs dependent on this hormone, notably vaginal atrophy, characterized by thinning and dryness of the vaginal walls, inflammation, and increased vaginal pH, primarily due to estrogen deficiency. Statistics show that approximately one-third of women not undergoing hormone replacement therapy experience symptoms of vaginal atrophy. It is estimated that 90% of these women suffer from symptoms such as vaginal dryness, itching, dyspareunia (pain during intercourse), post-coital bleeding, urinary frequency, and urgency, which can negatively affect sexual function and quality of life.

Given the progressive nature of vaginal atrophy symptoms and their lack of spontaneous recovery, untreated cases may worsen. Clinical studies indicate that both hyaluronic acid and vitamin E reduce the severity of vaginal atrophy symptoms, with hyaluronic acid demonstrating significantly superior efficacy. These compounds’ hallmark feature is their ability to retain large amounts of water and form a gel-like structure in tissues, promoting moisture retention, facilitating tissue repair, and enhancing the mucosal barrier function of the vagina.

In knee osteoarthritis treatment, sodium hyaluronate is administered via intra-articular injection. It is also used during arthroscopic surgeries as a temporary substitute for synovial fluid to improve joint function. Both hyaluronic acid and sodium hyaluronate are employed topically to accelerate wound healing, treat oral mucosal lesions, and maintain moisture in inflamed areas. Therefore, hyaluronic acid and sodium hyaluronate are considered effective options for managing and treating vaginal atrophy symptoms.