Pharmacology and mechanism of effect:
Maca: maca is an adaptogenic plant. Adaptogens generally support the body in dealing with physiological, biochemical and
psychological stress factors, including changes that occur during the perimenopausal and postmenopausal years. Australian research involving perimenopausal and postmenopausal women has revealed that a concentrated maca preparation stimulates the body’s own production of oestrogens and lowers the concentrations of stress hormones, such as cortisol and the adrenocorticotropic hormone. It is worth noting that maca does not contain oestrogens or other hormones, and can therefore be a safe alternative to hormone replacement therapy. It has been suggested that the mechanism of action is that the plant sterols that are present may have a stimulating effect on the hypothalamus, hypophysis, adrenal glands and ovaries. Other endocrine glands that are modulated by maca are the thyroid gland and the pineal gland. Because of the adaptogenic properties and regulating function of maca on the endocrine glands, it is an important candidate for the holistic treatment of perimenopausal and postmenopausal symptoms. Another favourable effect of maca is that it can have a beneficial effect on bone density. Research involving animals has revealed that an extract of maca is effective in the prevention of osteoporosis when the production of oestrogen ceases, and that it can improve bone density.
Low oestrogen levels in post-menopausal women is one of the causes of osteoporosis.
Maca seems to have a normalising effect on the hormonal imbalance. Based on traditional use and by maca being prescribed by doctors who specialise in complementary medicine, it has been found that this can relieve the cramps, bloated feeling, headache and the aforementioned symptoms.
Many sexual problems relate to a lack of sex drive in both men and women or erectile disorders in men. Research has shown that maca can possibly improve sexual functioning in men and women. Animal studies involving rats and mice have shown that maca boosts libido. Furthermore, after taking maca, increased androgen-like effects were seen in rats. Maca contains a relatively high concentration of amino acids, such as tyrosine and phenylalanine which are precursors of neurotransmitters and also determine sexual functioning, and also arginine that plays a role in the formation of nitric oxide, which combats impotence in men.
Ashwagandha: Research has shown that an extract of ashwagandha increase lipids metabolism. This plant increases the production of antibodies and has a significant activity in controlling the physical and chemical stresses. Also, the extract of this plant, by creating the effect of iron ions rejuvenation, can produce antioxidants effects and increase body iron. Ashwagandha improves short-term memory and treatment of amnesia disorders. It also increases significantly the concentration of blood hormones, the number of red blood cells, the number of white blood cells and platelets.
This extract may induce the synthesis of nitric oxide synthase expression, probably by acting at the transcriptional level, and the increased nitric oxide production.
Eleutro: Extracts of the roots have an adaptogenic effect
that produces a non-specific increase in the body’s defence against exogenous stress factors and noxious chemicals. The roots also stimulate the immune system, and promote an overall improvement in physical and mental performance.
An increase in the resistance of rats to adverse environmental condition such as stress, inactivity, or chemicals
was observed after oral administration of a 33% ethanol extract of the roots. The antistress or adaptogenic effects of Radix Eleutherococci are produced through metabolic regulation of energy, nucleic acids and proteins of the
tissues. The root extracts increase the formation of glucose-6-phosphate, which in turn decreases the competition between the different pathways of its utilization. The plant root reduces blood sugar and subsequently increases glycogen synthesis and high energy phosphate compounds. Research shows that the plant reduces stress, increases libido and alleviates digestive disorders. Eleutro also improves the function of white blood cells and improves the body’s ability to fight infection.
Rhodiola: The systematic study of the pharmacological effects of R. rosea, begun in 1965, found that small and medium doses had a simulating effect. In contrast, larger doses were found to have more sedative effects. Small doses increased the bioelectrical activity of the brain, presumably by direct effects on the brainstem ascending and descending reticular formation. Further studies showed that medium range doses, unlike tranquilizers, enhanced the development of conditioned avoidance reflexes in rats and facilitated learning based on emotionally positive reinforcement. Overall, in small and medium doses, R. rosea stimulated norepinephrine (NE), dopamine (DA), serotonin (5-HT), and nicotinic cholinergic effects in the central nervous system (CNS). R. rosea may affect emotional tone by influencing neurotransmitter monoamine levels in nerve tracts involved in the regulation of mood, anxiety, and emotion in the amygdala, hippocampus, hypothalamus, and midbrain. The stimulation of nicotinic cholinergic activity in the emotional circuits of the limbic system may also contribute to these effects. Alterations in monoamine levels underlie this complex spectrum of psychotropic activity:
stimulating, tranquilizing, anti-stress, and antidepressant.
roseacan help patients with depressive syndromes, mental and physical fatigue, memory loss and cognitive dysfunction from a variety of causes, sexual dysfunction, and menopausal-related disorders. A number of studies have shown that R. roseaincreased physical work capacity and dramatically shortened the recovery time between bouts of high-intensity exercise. Athletes given R. rosea had statistically significant increased shooting accuracy, less arm tremor and better coordination. R. rosea improved recovery time, strength, endurance, cardiovascular measures, and coordination. R. rosea increased essential energy metabolites, adenosine triphosphate (ATP), and creatine phosphate in the muscle and brain mitochondria . It may also enhance the ammonia reassimilation and energy metabolism of the cell by increasing ATP, ribonucleic acid (RNA), protein, and amino acid synthesis. R. rosea, like other adaptogens, enhanced thyroid function without causing hyperthyroidism. In addition, the thymus gland functioned better and was protected from the involution that occurs with aging. Egg maturation was enhanced in rats and an anabolic effect in males (increased muscle building and gonad strengthening similar to effects of low-dose testosterone) was observed in a number of species. Administration of rhodosin (extract of R. rosea) to sexually mature female mice, reduced the resting period from 3.8 days (control) to 2.2 days (rhodosin treated). In the majority of rhodosin treated animals, the number of growing follicles, the oocyte volumes, the accumulation of RNA in oocyte cytoplasm, the proliferation of the lining and glandular cells of the uterine horns, and the preparation of uterine mucosa for fertilization all increased.
Side effects: No adverse effects are expected in the recommended dosage unless the patient is allergic to the plant used in the medicine.
Precautions and adverse reactions:
Not intended for use by persons under the age of 18
Not for Use by pregnant or lactating women.
Consult a doctor or pharmacist if you are allergic to any of the ingredients in medication.
Do not use in diseases such as breast cancer, endometriosis, ovarian cancer, uterus cancer and uterus fibrosis, which is affected by estrogen hormones, the use of this drug is prohibited because of hormonal changes.
It is not permissible to use this medication for high blood pressure, cardiovascular disease and diabetes.
It is interrupted by anticoagulants.
Consult a healthcare practitioner before use if you are taking prescription medicines
Keep out of reach of children